Name: Novel (Trans)Dermal Drug Delivery Strategies: Micro- And Nano-Scale Assessments (en Inglés)
Price: 172.87 USD
Availability: InStock
Author: Hazel, Garvie-Cook
ISBN: 9783319804538

portada Novel (Trans)Dermal Drug Delivery Strategies: Micro- And Nano-Scale Assessments (en Inglés)

Formato

Libro Físico

Autor

Garvie-Cook Hazel

Editorial

Springer

Idioma

Inglés

N° páginas

114

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 0.7 cm

Peso

0.20 kg.

ISBN13

9783319804538

Categorías

Equipamiento y técnicas médicas
Química nuclear, fotoquímica y radiación
Tecnología de los plásticos y polímeros
Tejidos y fibras
Ingeniería aplicada de polímeros y composites

Novel (Trans)Dermal Drug Delivery Strategies: Micro- And Nano-Scale Assessments (en Inglés)

Garvie-Cook Hazel (Autor) · Springer · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Novel (Trans)Dermal Drug Delivery Strategies: Micro- And Nano-Scale Assessments (en Inglés)"

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.